Mediterranean and Low Carb Diets Shine in Study
A landmark study comparing Low fat, Low carb and Mediterranean diets over a 2 year period has shown low carb and Mediterranean diets to be favorable alternatives to low fat. The study looked at weight loss, blood lipids, glycemic control and inflammation.
Let's explore the study details and see what applications may arise from it.
Study Details
Participants:
Middle aged (mean age 52) and mildly obese (BMI 31) randomized to 3 diets:
- Low fat/restricted calorie (1500 cal - women, 1800 cal - men)
- Mediterranean/restricted calorie (same caloric intake as low fat)
- Low carb - no restriction on calories
Results
Adherence:
After two years, adherence to their respective diets ranged from more than 90% in the low-fat group, to 85% in the Mediterranean diet group, to 78% in the low-carb group.
Side note: Participants in the trial ate their main meal of the day--lunch--in the workplace cafeteria, where food choices were carefully controlled and labeled. On-site dieticians worked regularly with participants to help them adhere to their diets.
Weight Loss:
| Group | Low-fat (lbs) | Mediterranean (lbs) | Low-carb (lbs) |
| All patients | -6.4 | -9.7 | -10.3 |
| All completers | -7.3 | -10.1 | -12.1 |
| Men | -7.5 | -8.8 | -10.8 |
| Women | -0.2 | -13.6 | -5.3 |
It's interesting that women (oddly, there weren't very many of them in the study) fared far better in the Mediterranean group.
Lipid Changes:
| Parameter | Low-fat (mg/dL) | Low-carb (mg/dL) | Mediterranean (mg/dL) |
| HDL | +6.4 | +8.4 | +6.3 |
| LDL | -0.05 | -3.0 | -5.6 |
| Triglycerides | -2.8 | -23.7 | -21.8 |
| Total cholesterol/HDL ratio | -0.6 | -1.1 | -0.9 |
Inflammation:
The level of high-sensitivity C-reactive protein decreased significantly only in the Mediterranean-diet group (21%) and the low-carbohydrate group (29%), during both the weight-loss and the maintenance phases.
Blood Glucose/Insulin:
Among the 36 participants with diabetes, only those in the Mediterranean-diet group had a decrease in fasting plasma glucose levels. Insulin levels decreased slightly in all groups, with no significant differences between them.
What to do with this
By now you are probably sick of hearing about these studies. Perhaps the best conclusion that can be drawn from this study is one that most of us know already - that there are different paths to different dietary patterns can produce favorable health results.
The study is a comprehensive one, but not without its flaws. The adherence rates are artificially high due to the partially controlled environment and the consultations with dietitians. Also, energy expenditure was not factored in, which can account for a significant piece of the health/weight loss picture. I also would have liked to see body composition measurements in addition to scale weight.

A couple of points.
(1) It's interesting that the Mediterranean diet showed the least amount of weight regain when compared to the other two.
http://content.nejm.org/cgi/content/full/359/3/229/F2
That suggests that the Med diet may potentially be better for long term consequences.
(2) Since the study was limited to two years, it doesn't tell us much about the long terms consequences for each diet. One of the big issues for those concerned about diet is long-term weight maintenance, not simply short term weight loss.
ReplyAnother thing that strikes me as curious is that the fact that the low-fat diet had the highest adherence rate but produce the lowest weight loss. Thus, even though the participants in the low-fat and Med diets were supposed to eat the same number of calories per day, the Med dieters lost more wieght. This suggests that the low-fat diet had the highest rate of cheating.
ReplyI agree that having a dietitian on site can skew the adherence statistics. I think we would all be more likely to maintain a diet or eating change if we had a professional constantly helping us. I think this doesn't truly show how likely someone is to adhere to any of those diets.
ReplyI wonder about the idea of low fat diets-- do they get adequate amounts of the good fats?
I don't go low carb or low fat... I go restricted Calorie and as nutrient dense as possible!
ReplyMe too. I pay attention to calories and try to eat the healthiest foods possible - plenty of fruits and vegetables, lean proteins, good sources of fat, and whole grains.
ReplyI wonder too, as there were no specific instructions as to fat intake except to reduce them - which is quite backwards and not conducinve to healthy eating. That said, you can easily eat a healthy diet at 30% fat if you focus on eating good fats and include adequate protein and good carbs.
ReplyThat's how I eat too...I try to get the most nutrition for my Calories. I think that sort of fits in well with the Mediterranean diet...lots of fruits, veggies, fish, olive oil, etc. It's a much better way of eating than following a low-fat diet that's full of fake-fat foods or a low-carb diet that's full of fake-sugar foods.
ReplyCalorie restricted and macronutirent suffcient here. I've been successfully eating the Zone diet for over 13 years with amazing results. I've maintained a 100 pound weight loss for 13 years, I no longer need the blood pressure meds I'd been on previous to the Zone, and I have excellent labs every year.
Replywow! that's impressive! I need to lose a hundred pounds myself. I hve already lost 30 although I have bounced up and down a little this year. Now I am back on track and look forward to every seven or 8 lbs I lose. Any tips? Congratulations on your long term commitmant to keeping it off!
ReplyLow-fat diets are fundamentally flawed in concept. We have good research records on literally thousands of native and pre-industrial cultures who maintained levels of health vastly better than modern western man. None of these societies, absolutely none, restricted fat consumption. In fact, the majority of them sought out as much dietary fat as they could obtain.
Gary Taubes' "Good Calories, Bad Calories" is a bit of a boring slog to read. But it shows in great detail how the whole low-fat mantra was enshrined by the Government and the medical establishment with virtually no strong supporting evidence.
It seems to me that most modern diet research indicates that we should eat as much pre-industrial food as possible. In other words if your great-great-great-grandmother wouldn't recognize something as good food then don't eat it.
ReplyDiet studies are extremely hard to do because of the huge number of variables. All sorts of things can skew the results. The most significant aspect of this study’s results is the difference between the men’s and women’s loss in all three diets. No definite conclusions can be drawn from it as gender differences was not the focus, but it hints at the greater picture.
ReplyOf note is that calories were unrestricted only on the low carb diet. Eat all you want, and not worry about insulin.
It is insulin, after all, that causes fat gain or retention. This points out the lack of success in the low fat group, metered only by caloric restriction, in its efforts to induce weight loss. It is the inferior route.
ReplyI'm impressed that the Atkins group was able to lose weight and keep it off without conscious caloric restriction. I guess there's just so much bacon you can stand. The Atkins group, like the other two groups, did unconsciously restrict their caloric intake. All three groups cut calories by about 450 per day, compared with baseline intake. I believe the Mediterranean diet does have documented health benefits: prolonged life, less cancer, less dementia, less cardiovascular disease. But weight loss with a Mediterranean diet does require conscious caloric restriction. I have to agree with the study authors that the Atkins diet may be one of the best for people who need to lose weight, but who refuse to consciously restrict caloric intake.
BTW, the Atkins group had the highest drop-out rate.
-Steve
Replyyes - the impact of the Medi diet on glucose control was especially surprising. I would have guessed the low carb group may have come out on top. Interesting you mention bacon burn-out - I read somewhere that the Atkins group also restrcted animal fat. Anyone else hear this?
It's also interesting how the females fared so much better in the Medi group. I would love to see a follow-up with more female participants.
Also noteworthy - the study had funding from the Atkins Foundation. I don't put too much credence in this as the methodology is more important, but it is worth mentioning.
ReplyMike H.
I read that the low carb dieters were encouraged to find their protein and fat from vegetable sources. It would have been nice if they had defined that a little better.
ReplySince the test was run in Israel, I don't think you'd have a bacon burn-out...
ReplyThey were in Israel - I highly doubt bacon was ever on the menu, or cheeseburgers (cannot mix meat and dairy), or steak topped with blue cheese (same reason)...butter wouldn't be used in cooking of meats or poultry, or even vegetables if they are on the same plate!
But I do know the researchers did not limit animal proteins, nor did they expect the low-carb dieters to try to follow a 'vegetarian' low-carb diet....which is why Ornish's reaction was kind of funny - he didn't bother to ask the researchers before he penned his tirade in Newsweek!
ReplyYou know, anytime I read anyone - especially a "medical professional" - dismiss the Atkins diet as one that means you eat bacon around the clock (or hamburgers, or red meat, or whatever exaggeration they want to pull) it makes me instantly question their ability to do their job correctly. How do you keep up to date with your practice if you instantly dismiss any additional information that might benefit your patients? Medicine's very heart lies in accepting new benefits and treatments.
As anyone who has done their research knows, the Atkins diet does not encourage you to eat bacon all day. Nor even red meat. It does encourage you to eat healthy amounts of protein and low carb vegetables. Your protein can and should be found in turkey and chicken than bacon.
Moreover, Joe Schmo who isn't worried about his health at all is far more likely to indulge in bacon or red meats than the person on the Atkins diet.
Replyatkins works fine for me. somehow, i never have carb cravings.
but i'm not sure if i'm on a pure atkins or a modified? i just eat lots of brocs, lean meats & nuts. maybe a little fruit once in a while.
and i take about 3500 to 4000 cal a day.
what diet would you call this?
ReplyI find it quite intersting that men lost double the amount on low carb than women did and lost 7x more on the low fat ... makes you wonder:
ReplyIt's been amusing to see the various interpretations of this study in the headlines:
"Atkins, Low Fat, Low Carb weight loss choices remain blurred"
"low carb better than low fat for weight loss"
"low carb diet effective at helping weight loss for a short term"
"healthy diets have advantages despite insignificant weight loss".
"unrestricted low carb diet wins hands down"
It's funny to see how the study is being spun. It's also interesting to see news outlets relegate the study to a low carb vs. low fat issue.
ReplyThe Atkins diet is not an all-you-can-eat bacon diet. I just thought I'd put that out there since everything I hear from people who haven't read the book is "The Atkins diet is just butter and bacon, it's so unhealthy."
ReplyIt frustrates me that they "modified" the low carb diet as they did. I am fairly certain that if they had had the participants do by-the-book Atkins, there would have been far greater weight loss and improved lipid profiles.
To address some issues brought up above...
The researchers based the low-carb diet explicitly on Atkins New Diet Revolution of 2002. In their study, saturated fat was "not specifically restricted, but moderation recommended." For the Atkins cohort, "The intakes of total calories, protein, and fat were not limited. However, the participants were counseled to choose vegetarian sources of fat and protein and to avoid trans fats."
I don't recall if Dr. Robert C. Atkins recommended "vegetarian sources of fat and protein," nor how much. Vegetarian fats must be vegetable oils and nuts. To an Atkins aficionado, what would be so special about vegetarian proteins?
The research was "supported by" (funded by?) the Nuclear Research Center Negev, the S. Daniel Abraham International Cneter for Health and Nutrition, and the Atkins Research Foundation.
-Steve
Reply"The research was "supported by" (funded by?) the Nuclear Research Center Negev"
The NSC Negev in Dimona, Israel is the site where the study was conducted. The Atkins Research Foundation funded the study.
ReplyI think this link presents the study in a fair, unbiased manner.
http://www.nytimes.com/2008/07/17/health/nutrition/17diets.html?partner=rssnyt&emc=rss
I feel the bottom line is the participants did poorly on all of them. The "diet" is not the weak link :-(
ReplyDiet research is hard to do, and this study benefited from having a relatively controlled setting (workplace with main meal being served there). This is also a weakness, because few in the real world have that much structure and support. Take home for me is that even with almost ideal conditions it is hard to lose much weight, but weight can be maintained after the initial six months and the health benefits continue in the maintenance phase. Also, the study does help us (a little) choose what kinds of foods we may add or subtract from our permanent diet (lifestyle), as opposed to a temporary weight loss diet. So, for example, I may decide to add more fish and chicken (and less red meat), more Tabouli (I love it), and less sugar and starch (if I cut way down on these, I won't have to count Calories so much). Nothing we didn't already kind of know, but this is reinforcement for that. The gender differences are intriguing, but probably not that significant since only 16% of the subjects were women.
ReplyYou forgot to mention that they only lost weight for 6 months -- the rest of the time was spent regaining.
Many of the men dropped out also -- and they just used their last weight as an end weight, making it appear as though they'd maintained.
ReplySusan, the study authors don't provided the drop-out rate specifically for men (unless I missed it during my three reads). The drop-out rates were: 10% for low-fat, 15% for Mediterranean, and 22% for low-carb. These rates are a strength of the study, not a weakness.
So most people hung around for the 24-month study. You could indeed argue that many of them were not actually fully compliant with diet guidelines for 24 months. I expect that is the case in reality.
Note that the low-carb dieters were not following the program they were given. At 24 months, the low-carb dieters were getting 40% of their daily calories as carbohydrates. The other two groups were eating 50% of energy intake from carbs. This still seems like a lot of carbs to eat on the Atkins diet. A gram of carbs has 4 calories. The stated carbohydrate goal for the low-carb group was a maximum of 120 grams of carbs daily, on a diet of 1800 calories. So 120 grams of carbohydrate should be 27% of total daily calories, not 40%. At no point did the low-carb group reduce their average percentage of calories from carbohydrates under 40%. OK, maybe be in the first two weeks but those data are not reported. On an 1800 calorie diet, 40% of calories from carbs would be 180 grams. [I'm sure someone will correct me if my math is wrong!]
So the low-carb group may well have achieved greater weight loss if they had been more compliant. But you could say the same about the low-fat and Mediterranean cohorts.
-Steve
ReplyThe main thing I noticed from this study was that the average weight loss was around 10 lbs, in 2 YEARS! I acknowledge that there were some health benefits, but from a fat loss perspective these results are very poor.
Healthy fat loss doesn't have to take this long at all. In fact, you can lose 5-10 lbs in 1-2 months and enjoy many of the same health benefits obtained above.
Of course, the media is always looking for the next best thing. In reality, we all know that there are many different ways to lose fat and promote health at the same time.
ReplyThe other thing about this study was that I think it's highly unreplicable... not only because you're unlikely to find your workplace changing the entire cafetaria, having dieticians on site and even going as far as labelling food - but one of the interesting features of this study was the high amount of spousal support to continue with the diet options after hours. Well 86% of the participants were men. I can't help wondering if 86% of the study were women if they would have received the same kind of spousal support given that (in general) women are conditioned to be the caregivers and food prepareres.
ReplyJohn, I think the weight loss was so low because they lost and then regained. Yes, you could lose 10 pounds in two months -- but would be still be 10 lbs lighter when the study ended?
ReplyAll three groups lost all their weight, on average, during the first six months, then started a gradual return towards baseline weight. The low-carb group lost more than the others during the first six months - 14.3 lb. The Mediterraneans re-gained the least - looks like about a pound from the graph in their report. I hadn't noticed it before, but this minimal re-gain for the Mediterranean cohort is intriguing.
As many have pointed out, these are pretty small numbers overall. Average body mass index at the outset was 31. That's a 5-ft, 10-inch person weighing 216 lb.
-Steve
ReplyI’m wondering what other people think. I’ve been doing some research on healthy eating and low carb diets in particular and came up with this one site called OpposingViews.com where there are debates by experts on various subjects.
There is one debate called: “Are Low Carb Diets Healthy?”. I like the idea that these people are experts in their fields, but this one guy says something that gives me pause. He says something to the effect that eating whole plant foods is associated with having good health but diets high in animal protein and fats are not. He also says that in a global sense, a sustained low carbohydrate diet which comes mainly from animal foods creates significant challenges for the planet and also other health issues for people such as antibiotic resistance.”
What do you think he means when he says that a diet which comes primarily from animal proteins is bad for the planet? That’s the first time I ever heard that. If you have time, take a look and let me know what you think by posting your comment. Thanks! http://www.opposingviews.com/questions/are-low-carb-diets-healthy
ReplyHi Wendy!
ReplyWhen he makes that statement, he is probably referring to the amount of land and resources it requires to raise meat sources of protein, versus land usage for a plant centered diet.
While you are pondering that, consider this. If everyone ate a healthy, non altered or processed food diet, we would run out of food long before there was enough to sustain our species :-(