Acomplia Side Effects: The Story You Must Read
UPDATE: May 2007. The drug has been re-named Zimulti in the US.
UPDATE Jun 13 2007: An FDA advisory panel of outside experts unanimously recommended that the regulatory agency not approve the novel weight-loss drug for sale in the United States. It is unlikely that this drug will be approved before 2010 (if at all).
UPDATE July 1 2007: Sanofi has now withdrawn it's application for approval in the USA.
Background
Rimonabant (brand name Acomplia) has been pitched as the blockbuster weight loss drug of the decade. The company manufacturing the drug, Sanofi-Aventis believes that sales will reach $5.2 billion per year by 2010. That is a staggering amount of money.
Investors are getting swept up in the buzz, and desperate consumers are falling over themselves to get an opportunity to try the drug. However it is currently before the FDA awaiting approval - which some believe may come during early/mid 2006. Acomplia blocks cannabinoid (CB) receptors in the brain. The CB receptors are believed to play a role in controlling food consumption and dependence / habituation. People often refer to the cannabis-induced "munchies" or hunger pangs. Acomplia attempts to do the opposite.
What is an Acceptable Risk?
In the scramble for profits and quick-fix obesity solutions - no one has bothered to raise questions about the long term side effects. It is up to the health authorities to determine what is an "acceptable risk" based on the data from the clinical trials conducted recently.Carol (not her real name) knows about the risk - and it is anything but acceptable. I recently corresponded with Carol, who participated in a Rimonabant drug trial.
With a long history of dieting, Carol began the trial at a weight of 13 stone 1 pound (183 pounds). With a daily dosage of 20mg, Carol noticed two immediate reactions; She was less hungry, and she became very tearful and depressed. She began to lose a pound or two per week (without being on a diet or exercise program).
Psychosis?
However things went from bad to worse. "I also felt nauseous quite often and in a period of 3 months vomited 6 times. As the trial progressed I became more and more depressed. I felt suicidal most of the time." In her desperation to lose weight, Carol stayed on the drug, but slowly descended into psychosis "I couldn’t sleep and when I did I had terrible nightmares". Carol experienced more graphic symptoms of psychosis (such as self-inflicted violence). She has since been on anti-psychotic medication for over a year, and has gradually improved."I lost my health and happiness because of these pills and experienced the most wretched time of my life". Carol also added "My relationship with my partner never recovered from him having to care for me and we split up at the end of last year."
To add insult to injury, the 20 pounds that Carol lost in the trial came back on within 3 months. Carol reports that her appetite "came back with a vengeance".
Not Alone
According to the results of the 1st year of clinical trials, patients taking the 20mg dosage of Rimonabant reported 50% more adverse events leading to discontinuation, than those in the placebo group. Of course Carol's experiences must be kept in perspective - most people had no adverse side affects.
» Note the increase in psychiatric disorders as dosage increases
What is an Acceptable Risk?
Is even one persons terrible experiences an "acceptable risk"? Maybe Acomplia will end up being prescribed to only the most "at-risk" obese patients - but who decides where that line lies?Cover Up?
You will not read about Carol's experiences in any published paper. The data from the 2004 trial that Carol participated in has not (yet?) been made public. Sanofi funded the trial and holds the results.There Will Never Be a Perfect Weight Loss Drug
In amongst the flurry of hype and expectation over this new "wonder drug", someone needs to take a long hard look at the whole concept of miracle weight loss cures. For the sake of 20 pounds of weight, Carol damaged her mental health, and her relationships.Carol strongly cautions anyone with any history of depression to be "very careful" about taking Acomplia/Rimonabant - "Being thinner is not worth screwing up your mental health."
$5.2 billion dollars estimated per year. With that sort of money being generated, who will care if a few people lose their minds?
Sanofi-Aventis "Because Health Matters"
2005 Worldwide Pharma Sales: 27,311 Million Euros (33 Billion USD).
100,000 employees worldwide (including a sales force of 33,000).
Present in more than 100 countries.
It is possible that Acomplia may be marketed as a Cardiovascular medication. US health insurers generally cover cardiovascular medication.
I have only scanned through the comments listed, but I just had to jump in and tell you of my experience with
Acomplia.
First of all, I am buying it from a UK pharmacy that does not require a script. It is VERY costly--$540 for 84 tablets. But, so far I am very glad that I spent the money to buy it. I have been taking it about 1 month and have lost 10 lbs so far.
I, too, have suffered from depression in the past but have not had any problems of that sort with Acomplia. In fact, the only side effects I've had are mild hiccoughs (mostly the first day) and an occasional wave of nausea. The nausea occurs 2 to 3 hours after taking the tablet and, although it's an almost overpowering sensation, it passes within 60 seconds. This has happened less frequently after 2 weeks. I have never actually gotten sick.
WHY I'M TAKING ACOMPLIA:
I am a 60 year old female and between menopause and years of yo-yo dieting, my metabolism is a train wreak.
I exercise for about 90 minutes a day, 4 or 5 days a week; I eat a low fat, low cholesterol diet--heck, I even weigh and measure everything I eat. But still the weight would not come off--mostly because my appetite prevents me from keeping my calorie count low enough.
I'd lose a few lbs. and gain them right back.
I am not clinically obese--but overweight enough for it to effect my health: esp. high cholesterol which is partially genetic. In the last 3 years, my cholesterol climbed from the low 200's to the low 300's--for no apparent reason. I cannot take any of the cholesterol medications (I get the supposedly rare--but serious side effect and hurt from head to toe) There is a strong history of stroke and artery blockages in my family, so I feel like a walking time bomb. My doctor tells me that my only option is to drop 15 to 20 lbs.
And Acomplia seems to be helping me do that--and without much difficulty. I have not made any changes in my diet or exercise program, but I have way better control of what and how much I eat. In fact, I feel so much more in control that my self esteem has sky rocketed.
One thing I want to stress is this: Acomplia does NOT prevent you from overeating. If you are not truly motivated to lose weight (or quit smoking) this will not help you. It has not totally removed my appetite or cravings. But it has helped to give me better control
(the $6 I have taped to the refrigerator door to remind of how much I'm paying each day to lose weight doesn't hurt either!)
Acomplia is like any other drug--it will work great for some people; not at all for others; and will cause serious side effects in some. The way I see it, Acomplia is not a magic bullet--but if you can afford it and it doesn't cause you serious side effects, it can be a useful tool--along with diet and exercise--in losing weight.
ReplyHi
ReplyMy doctor says i have to go on these pills as i am obese, after reading some of the comments i am now a little concerned i had deppression after loosing my baby at five month old, 23 yrs ago and it comes and gos even now. I dont like what i am reading can anyone say anything good about this drug or do i stay fat. PLEASE CAN YOU GIVE ME GOOD COMMENTS THANKS SUE.
I'm all for diet and exercise, but I will certainly take this helpful little pill.. Damn the side effects! Everything has side effects.. EVEN exercise! I've got bad shoulders, (from lifting weights!) numerous painful knee surgeries, and bad ankles (from various sports throughout the years!) I'm thirty now and my body feels fifty.. Will I really be able to maintain an adequate exercise program when I AM fifty? I know my genetics and if this pill will help avert the numerous cardiovascular problems I am likely to develop, I will gladly accept these minor risks!
ReplyHi everyone
My doctor has given me Accomplia today and after going on the web to find out about it, found this site - and I'm not too sure about it now as I have also been very depressed in the recent past (1999). Depression problems return occasionally and I need tablets to sort it out again. Having said that, I really need to lose weight urgently, so I think I may try these for a month and see how I go with the added information I now have so I will keep a close eye on things regarding depression too.
Butterfly
Replymy husband is in an accomplia drug study that started at the end of september and goes for 33 weeks. While he has lost weight(16lbs), he's mostly lost his personality. He is depressed, moody, short-tempered, surly, and nauseous most of the time. He looks at food and loses what little appetite he manages to have. Previous to this medication, he was the exact opposite of the above description. He won't quit the study either. He is somewhat aware of the personality change. So far I have been pretty tolerant, but I am not sure that i can make it until May. He only has about 15 pounds left to lose.
ReplyThere are many posts of comparing "my problem or solution to yours" and attacking each others posts. Every one is different and has validity in there ouw situation.
Regarding Acomplia and side affects. It is not uncommon for different people to respond differently to any perscription drugs. These Clinical Studies are done in a controlled setting. There is No Safe Drug, only safe doses, and there are always risks. If you want to try Acomplia the best thing to do is talk to your Dr. He or she can help you decide, based on your medical history.
ReplyTreatment-emergent depression and other side effects are a risk factor of any new drug. Stopping treatment is sometimes the only decision. This is not to say that Acomplia is a bad drug, It IS a New Drug. I am currently awaiting FDA approval for sale in the US, I also work in the Biomedical Industry and New Drug Development. Big Pharma IS out to make money...thats no supprise. The FDA IS out to protect US consumers. Before you comment, do your homework. www.fda.gov/foi/warning.htm. This is public information
I took Acomplia for the first time a week ago. After 5 days on the drug I had the most bizarre side effects. As soon as I woiuld start to fall asleep, I would get an electric shock through my entire body, causing me to jump up with a start. It was quite painful.. This happened once on the 5th nite of taking the drug, again once on the 6th nite, and on the 7th nite it was all nite long. I never slept. I stopped taking the drug 2 days ago, and the symptoms are slowing down, but are still there. I have not slept properly in many days. It was the most frightening experience. I swore if I ever got better, I would never take another diet drug.....and I will not.
ReplyWell, these are all interesting comments. Carolyn, who is 60 and has no metabolism left, I hear ya girl, I'm your clone. I will be starting my pills when they arrive and hope I have a positive and not negative result. If it's bad..I'll quit without a doubt but I am hopeful. If diet and exercise was the be-all and end-all, I would be a stick. Until I reached my 40's I never had a weight problem which I think makes it harder to have one now. Don't judge others based on what you think SHOULD work, not all overweight people are lazy face stuffers. There are a variety of metabolic conditions that can make losing weight a minor miracle.
ReplyCheryl, I don't judge you, but I believe you might wanna look at all that is causing your slowed metabolism and treat those first - and then if you still feel you need to take a pill, do it. Cause otherwise, it is kind of like putting turbo on a 1972 Volks rabbit. It won't help you much.
I'm not sure if you are on HRT, but even if you are, there is a good chance your doctor only gave you estrogen and ignored progesterone, and gave you synthetic estrogen, not natural hormones. In that case, your thyroid is probably shot too, it tends to be after menopause unless you got very good HRT and very early on. You need to have all the female and thyroid hormones tested, the free levels of them, and find a doctor that will bring all of them to the normal levels. Not to the very lowest of the acceptable range for thyroid, and not to "post-menopausal" normal for the female ones. To healthy pre-menopause levels, and to a level where you don't have any thyroid symptoms, if in fact you need to replace those.
Then another issue is loss of muscle mass with age. Weight training would be highly beneficial too. Otherwise I think you'll be taking drugs and going on strict diets and walking until you get blisters on your feet and you'll see no or poor results. Notice I'm not saying don't take the pills. Nobody really knows about these pills yet, they are too new, but even if they do work, they are the turbo, and until you get the rest of your metabolism back to normal, it will be little help at best.
Good luck.
ReplyJAN DIFFERENT STROKES FOR DIFFERENT FOLKS. I HAVE BEEN ON SYNTHETIC HARMONES PREMARIN AND PROVERA FOR EIGHT YEARS NOW. NEITHER GOING THROUGH MENOPAUSE OR TAKING SYNTHETIC HARMONES HAS AFFECTED MY THYROID. I HAVE HAD ALL THE TEST AND WORK CLOSELY WITH MY DOCTER. EVERY PERSON IS DIFFERENT AND WHAT WORKS FOR ONE PERSON MAY NOT WORK FOR ANOTHER. THERE ARE ALWAYS RISKS WITH ANY MEDICATION, BUT SOMETIMES THE BENIFITS OUTWAY THOSE RISKS.
ReplyThe love of my life is morbidly obese. We have tried and tried to help him lose weight but it has never worked. (We have REALLY tried.) Someday he is going to die from it and then our family will be left alone. If a pill could help him, then he should have the right to try it.
Replythe only thing that could ever work garanteed 4 weight loss is cocaine !no question's asked,it's the only thing you can be so sure to loose as much as you like..altho it's an illegal drug but it;s true..!!
ReplyMy sister has been in the hospital for 2 days now, with psychosis symptoms. She was taking the medicine Reductil. I just want to inform people that these medicines are not good. She is one of those desperate people who want to loose eight right away and this is what happened to her. My whole family is devastaded. You cannot find enough information online about these drugs and there are ads all over the place you can buy w/o prescription.
ReplyWhen I started the drug, after about 1 week my heart rate went up to circa 100 beats per second at rest and I began to feel very anxious, I spoke to my GP who suggested that I should try to tough this period out whilst my body adjusts to the drug, this I did and my heart rate after about 4 days returned to near normal (but not normal). I then had a reasonably trouble free period up to about 4 weeks ago when I have since been feeling nauseas for long periods of the day, occasionally vomiting. It is now getting so bad that I am actually thinking about giving this “wonder drug” up ……….. shame because it does actually seem to work.I started taking Acomplia 20mg 12 weeks ago. I have lost 8kg without to much effort.
ReplyI started acomplia 2 days ago. I am waiting for all the crazy side effects to come over me. I have to be honest and say its like I'm not taking it at all. I do not notice a thing. I am in need of a 80lb+ weight loss and have tried everything. How long does it take to notice a curb in appitite, etc. I am taking 20mg.
ReplyPlease help.
Dorothy
I just started acomplia, and am of course concerned about possible side effects. But i am a diabetic, having a hard time gaining control, and I want to see if this helps.
Any diabetics out there? Did it lower your blood sugar?
ReplyI'm in the UK - my DR agreed to give acomplia a go. I began to loose 1 - 2 lbs a week but found the nausea tricky to cope with and came off. I am going to re-try after xmas with my DR's approval. I don't believe I had any psychotic indications but did feel rather fed up - however work was going through a bad phase. The general view s that the longer you can tolerate the drug then the more likely it is that the side effects will diminish. Hope that's some help!
Reply30 pounds overweight.Ordered without a script from UK a couple of months ago. Used for one week. Side effect: Bolted up at night with what felt simalar to deep/severe leg cramping. Experienced residual tenderness in legs the follwing days. Went off script for a couple of weeks and went back on a few weeks later with same results. I am pretty sure that this was related to this script since I have never had an issue like this before or since I took script. I stopped taking it because it did absolutely nothing to suppress my appetite. I really wonder if I got some kind of knock off. It looked exactly as it should have but I still wonder since it was so useless. It was a big waste my of money!
ReplyHi,
I've been on Acomplia (20 mg) for a mere 2 weeks. I had to get off due to the horrible depression I've started slipping into (irritability, weepiness, unhappiness, just plain "I don't want to live in this world anymore"). Of course, there was no significant weight loss I could have accomplished in that time. I know 3 other people you've taken it and for them the effects ranged from 1 to 2 pounds a week. All of them went off the drug in the course of 2 month (longest) stating mood effects as the reason to stop.
ReplyI suppose with enough will power and no pre-disposition for depression, it is possible to use this drug in short spurs of 2-4 weeks to break the habit without any real damage to the mental health. If coupled with a good therapist and a personal coach, it could do wonders to one's will power not to overeat.
For those of us, whos BMI index is in normal range (
Please let me know when I can buy and where. thanks.Tired of being FAT. Michelle vollnogle
ReplyWith the onset of menopause I gained three inches around my waist but no real weight and ended up with high blood pressure and 300 cholesterol (+100 "bad"), all over the course of two years. For a full year I tried exercising 3 to 5 times per week/1 to 2 hrs at a fitness center and changing my diet (no butter, no ice cream, dessert only on the weekend, etc.) with almost no impact except for developing some muscles. (My husband, however, lost ten pounds.)My doctor suggested Accomplia because I was so fit, not overweight but over-fat with a 37% body fat at 5'8" and 154 pounds, not "obese" in overweight terms, but "central obesity" meaning middle aged spread. I started on blood pressure medications but after trying three different kinds, cannot tolerate them due to allergies. I began Accomplia 20 mg/day in August 2006 and in three months lost 12 lbs and now (more slowly) am down to 135 lbs, but more importantly down to 31% body fat. At first Accomplia made me a bit dizzy and occasionally nauseous but I realized I would forget to eat for hours. As long as I make sure I eat a small snack and drink plenty of water I am fine. Also, when I do get hungry, it can almost be painfully so and I really have to get something in my stomach immediately or I feel nauseous. One small glass of wine can make me feel drunk and two glasses can send me to bed with the walls spinning so I keep my wine to a glass with dinner. I have cut my dose to 10mg/day because I am concerned with what happens when I stop, am satisfied with my weight but still want to lose more fat in the hope that my cholesterol drops along with my blood pressure. For me, Accomplia has offered the chance to change my body type and perhaps live a few more years without any medications even though my entire family is on blood pressure medication. Of course not all medication works for everyone, as with me, the blood pressure medications caused severe allergic reactions. I am running out of options and hope that if I can reduce my body fat back to around 27%, my blood pressure will return to normal as it was then, along with my cholesterol. Two doctors have advised that my diet and exercise plans are as good as they can get. Accomplia doesn't just cut your appetite, it has an effect on how your body metabolizes what you eat. That was quickly apparent to me as I have since lost the three inches around my waist. I have fought to keep my weight normal my entire life, my siblings are extremely overweight and have high blood pressure, type II diabetes and other related illnesses. I was shocked to develop high cholesterol and blood pressure but am encouraged by the use of Accomplia. I know how difficult it is to control weight and am lucky to have a doctor who listens to all my concerns. I agree that you may need a combination of diet, exercise and drugs to maintain a healthy body. It is not always as simple as eat less, exercise more. Believe me, I exercised so much I developed osteoarthritis in my hips. Good luck to everyone, hope my experience helps. By the way, I live in Germany where Accomplia is approved but I have to pay for it myself (about $100 per month for 20mg).
ReplyI have been taking Acomplia for 2 months now, NO side effects, NOTIHNG, I lost a stone and 3 pounds and I stoped smoking. Sorry guys this am fine with it.
ReplyCarolyn, I am with you 100%. I've been taking Acomplia since October, having found an online source that will sell to the US without an Rx. My metabolism is all but shut down, from years of yo-yo dieting, pill-popping, and from hypothyroidism, which is now being treated (has been since 2002). I agree with what's been said here--this is no magic bullet. You have to want to lose weight, you have to watch your diet, and you have to exercise (even if it's just starting out with 10-minute walks around the block). For those who are expecting to feel some powerful difference when you start taking this drug, you will not feel buzzed like amphetamine-type diet drugs from the past, or any other drastic effects on your appetite. This is much more subtle, almost unnoticeable, and is meant to aid you in weight loss, coupling it with sensible eating and an exercise program (it's not meant to be instead of that, and it still requires effort on the part of the person taking it). What I have noticed is that my carb cravings are 100% under control, thanks to Acomplia and my desire to make it that way. Weight is coming off very slowly--I'm losing about a pound a week, if that.
My motivation is osteoarthritis. In August, I was about 70 pounds overweight and on 9/1, had surgery on my left knee for OA; my right knee is in pretty bad shape as well, and I'll eventually need surgery to repair shredded cartilage in that knee, too. My orthopedist told me that if I didn't start losing weight and taking care of my knees, I'd be facing a knee replacement within 5 years. First order of the day was to start losing weight. Knowing my difficulties in the past with weight loss in spite of diet and exercise (I used to train for and ride in cycling centuries--100 miles in one day--and was still 50 pounds overweight and couldn't lose), I decided to give Acomplia a shot, even though it's over $200 USD per month for me. It's working, and I'll keep taking it as long as I need to in order to drop the weight and save my knees.
Sorry for all you folks who have had adverse reactions to Acomplia. Not every drug is for everyone, and it's really unfair to say "this drug is bad and shouldn't be on the market" because a small percentage of people have these adverse reactions. It's also unfair to say that the solution to losing weight is simply to cut back on calories and get off the sofa to exercise. Been there, done that, and it didn't work for me because of my nearly nonexistent metabolism. This pharmaceutical company is not hiding the adverse reactions. I see all over that the drug is not for people suffering from depression, renal, or hepatic problems. How much more clear can that be? If you suffer from any of those, or any other affliction that they warn about, and you choose to take the drug anyway, you are running the risk of facing the adverse reactions. The warnings also state that depression-related problems are a known side effect, and that's regardless of whether or not you have a history of depression. Again, I think that's clear. For me, this medication is the answer to my prayers, and I'm sure it will be to countless others who struggle with obesity. It's not for everyone, but it's definitely for me!
ReplyPosting to add that I'm 51 and transitioning from perimenopause to full menopause. I've been treated in the past for depression, but was willing to take a chance with Acomplia in light of my current situation. I'm glad I did.
MNW, I also noticed my cholesterol level gradually rising over the past couple of years. I'm due to have it checked in March, and am hoping to see it go down this time.
ReplyFizz - after three months on Accomplia my cholesterol only went down 3 points, even with the weight/fat loss. We are giving it another 3 months but I began taking fish oil (we eat fish about 4 or 5 times a week). I also had to go back on a beta blocker, low dose this time, since although my bp improved, I am still hypertensive. Hot flashes have returned in full force, don't know how long this transition will last. Accomplia has at least helped me to feel/look fit and with the loss of weight, I no longer have finger/toe joint swelling and my hips are less problematic.
ReplyI have been on Accomplia since 1/8/07. Here I am only one month later and 16 pounds thinner. I no longer look at food the same. I look at it more as if it were a material item such as a nice car, I am thrilled at the results and have had no side affects.
ReplyI am in a clinical trial for Acomplia and after a long screening process have taken the drug for one week. I am experiencing insomnia, anxiety, nausea, diarhea, and itchy skin. I was told these symptoms happened to less than 10 percent of those on the drug. The dirty trick part of it all is when I am not nauseous I am ravenous. I guess the food cravings are because of the increased anxiety. So far I would have to say the drug DOESN't work and has wicked side effects. I may give it a few more weeks but I may drop out of the study. I worry about this drug. What are they not telling us? Why doesn't it work? I don't expect miracles but I didn't expect it to be this bad. What a nightmare!
ReplyIdon't usually get into this sort of thing- I.E> drug trials, and forums like this, for another. But I feel that this is too important to ignore.
I began the drug study for rimonabant four months ago and and was doing well until about three weeks ago when I awoke one morning and found that I hd lost sensation in my right hip area. with further investigation i found that the loss extended from the centerline of my lower abdomen(right side) and groin area, around my right side to the left buttock. That also included my rectal area. several days later I noticed that my legs were slowly becoming numb, and that several other areas of my body were also developing loss of sensation and hyper-sensitivity. That includes tingling, and feeling like i was walking barefoot on pea gravel. In the following several weeks, I have lost sensation in my feet and down the back of my left arm, from the tricep area to the hand. I have lost sensation in the upperleft chest area and that extends around under my left arm and to the left scapula area.
I am diabetic, but have had no problems controling my sugar levels and have had a stable program of control with no complications for the past four years. I, up to the time of the drug trial, had no neuropathy symptoms. I have not seen nor heard of any other adverse neurological problems, related to this drug. But, I don't believe in coincidences. I cannot believe that all these probles "just happened" at the same time that I started a drug trial. I contacted the group that was conducting the study and was told by them that the symptoms may be related to the drug and also a rash, that I didnot mention, I immediately stopped taking the drug. In the following week, the symptoms slowly stopped progressing and halted. In the past few days the symptoms also seem to have abated just a small amount.
just as a footnote. the study group has not yet told me that I was actually on the drug or the placebo, but I was experiencing weight loss without any change in eating habits or other factors that may have caused weight loss such as excercise (God forbid!.
ReplyI am not succeptible to suggestion that would cause similar results, either. I let the product do the talking. so, lgical deduction tells me that I was actually taking the rimonabant. The study group is in the process of unmasking ( double blind study) my case to ascertain I was actually taking the drug, but I feel that the results speak for themselves.
That's all I have so far. If any more of you have similar stories, I would encourage you to put them out here. It's a real bear having to try to type and not feeling half your fingers. Luck to you all.
Can anyone tell me where I can get without prescription and sent to US?
ReplyMy doctor here in the US wrote me a prescription for Acomplia 20mg, in which I ordered out of a pharmacy in Canada and was shipped to me from England. I was really quite impressed with my weight loss without really changing my diet. I did eat less, and within a month's time had lost 11 pounds. The side effects were somewhat minimal. Nausea was the most common side effect (which did subside over time) and some occasional muscular pain, but overall I was really impressed with the drug. The only drawback is that it is expensive, in addition, it is the first diet pill that I have taken that didnt make me feel anxious.
ReplySo far I have been on the drug for one week and it has been great. I have been able to sleep for the first time in months. Hey, I have not sleep walked, or feel depressed. I believe that certain medications are not meant for everybody. Maybe the drug will work great for other people just like it worked for me.
ReplyI have been on Acomplia for 6 months. If anyone wants some in the USA at cost, write me at caxlyn@cougars.com because I have 6 unopened boxes of 98 purchase in Germany.
Replyevery med. has side effects. I have fought with my weight for years, it has been an emotionsl struggle for me. I now have arthritis in my knees that prevents me from workin out regulary. If this drug will help me with my weight !!!! hurray!!!!there are an enormous amount of ed drugs on the market, than I am sure have side effects but they continue to sell it because if is for men problems.
ReplyAcomplia was a ground-breaking new breed of medication which targeted the body’s little understood endocannabinoid system when it was launched in the UK last June but it could soon have one or more rivals. Both Merck and Pfizer have similar drugs in Phase III clinical trials which are said to be producing very promising results. Merck has already announced that it intends to apply for regulatory approval in 2008 and it is believed that Pfizer will be aiming to seek approval at around the same time. There is another drug which works in a similar way to Acomplia under development by Bristol Myers Squibb but it is believed that the development of this product is significantly behind those of Merck and Pfizer.
ReplyThe way most doctors 'head ' em in, move 'em out' meaning, spend but a few rushed minutes (if they can get away with it) with their patients, it is too time consuming for them talk about side effects in most cases because this leads onto further chatting, and eventually a backed up, overbooked patient schedule. Having worked as an assistant in this area, I remember well the scenario.
Unfortunately, everythings gets too routine for most doctors and they forget about the human side of patient care. The reality of high insurance costs, the golf club fees, the lifestyle upkeep eventually takes over as the priority.
And MANY times have I witnessed a drug company rep passing by, dumping off samples and gifts to the doc. The next patient that comes in gets 'Here try this and let me know how you feel' (hasn't even read the info sheet - going just on the drug rep's quick blurb about it). This is very, very common.
I think a patient should be first skeptical of ANY drug prescribed and probe with questions and own research into it, and then weigh the pros and cons with a further discussion with the doc. Today with internet, this is instant and easy.
An allopathic doctor should not be the first choice in most cases anyway. One should ALWAYS try natural/alternative practices first before resorting to allopathy and drugs.
Ah, but it does exist. People love to sue whenever they can. Some legitimately, most because of the big money in it. That is real.ReplyI wanted to reply to say that when combined with some diet and exercise this stuff really does work. I started taking Acomplia back in Sept., along with an exercise and diet program using a device I found online which helps me carefully monitor both calories burned and consumed: www.bodybugg.com.
Since then I have lost 80 lbs, and am on track to make my 100 lbs goal by end of June, which would put me squarely in the "normal for my height" category. My doctor has been literally amazed - I first got Acomplia from one of the UK sites with an "online consultation" but after a couple of months my doctor actually gave me a prescription and I was able to get it from one of the Canadian sites for much less. My doc has continued to see me monthly to keep an eye on progress, but overall it's been just great. No side effects at all that I can see, after the first week when I did feel some anxiety. The effects of the drug do seem to have worn off a bit, but I still feel full much faster, and have the will power to resist urges and "just say no".
As I say, overall just great, and I wouldn't hesitate to recommend it to anyone.
ReplyI have been personally touched by the negative effects of Acomplia. My husbund has been a part of a US research study for a little over a year(Blinded so he would not know if was getting a placebo). I knew within a month that he was notthe same and suspected it may be due to the drug. He was having incedible results. Lost over 40 pound in 4 months with a hugely improved triglycerides and greatly improved fasting blood sugar.
ReplyAfter increased conflict in the home and bizarre mood swings, I asked him to get off the drug...he found out today what he was on.It was not the placebo..it was this miracle drug. I hope to get my old husbund back. We have been married 17 years and have never had the problems we have had when he was on the drug. He was depressed one day aggressive and argumentative a lot. Often not rationale.
Like my husbund, there aremany Americans who want to lose weight and they will find the drug works and may not get off of it when they need to. The risk of psychological effects far outweigh the benefits in my opinion.
I have been taking acomplia now for almost 3 months. I have lost 1 stone in weight. The side affects have been mild and few. At the beginning i had slight insomnia, but i do sometimes get this on and off. I am feeling slight anxiety lately, but then again it could be that my life at the moment is quite hectic.
ReplyI have noticed that my appetite has returned a bit. I'm still not eating between meals, but at night time i do feel hungry. As i suffer from insomnia it can make it very difficult staying good all night. Also my weight loss has stopped for the last two weeks, as i am struggling.
Can anyone help?
I am on my 4th day taking Acomplia. The most noticable effect is the total lack of interest in smoking, and I have been a smoker for over 30 years. I have a reasonable appetite, not my usual raging hunger, which makes a nice change.
ReplyEven if I dont loose weight, the bonus of not wanting to smoke is a massive plus for me.
I RECENTLY PURCHASED ACOMPLIA...THE DOCTOR PRESCRIBED IT TO ME BUT IT IS STILL NOT IN THE MARKET IN THE U.S.A., SO I WENT TO REYNOSA, MX WHICH WERE $145.00 FOR A TOTAL OF 28 PILLS. I HAVE BEEN ON ACOMPLIA FOR A TOTAL OF 4 DAYS AND I FEEL WONDERFUL.. I AM HOPING I WILL HAVE RESULTS GRADUALLY....IF I CAN BE OF ANY ASSISTANCE TO ANYONE WITH THIS PRODUCT ....I KNOW HOW HARD IT IS TO PURCHASE THIS..GRACIE
ReplyHi!
How are you? how can I get this 28 pills.I really need them.Please give me any useful informations.
thanks,
Florence
Reply